|
In molecular biology, VanY are protein domains found in enzymes named metallopeptidases. They are vital to bacterial cell wall synthesis and antibiotic resistance. ==Function== VanY is involved in bacterial cell wall biosynthesis and metabolism. VanY D-Ala-D-Ala peptidases provide resistance to the antibiotic vancomycin on some strains of enterococci, and are therefore drug targets. VanY is a Zinc-dependent D,Dcarboxypeptidase enzyme that cleaved the C-terminal residue of peptidoglycan precursors ending in R-D-Ala-D-Ala or R-D-Ala-D-Lac. ==Substrate== The substrate specificities of VanX and VanY ensure that essentially only precursors with low affinity for the glycopeptide antibiotics are available for peptidoglycan synthesis in resistant strains. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「VanY protein domain」の詳細全文を読む スポンサード リンク
|